Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed at the Institute of Molecular Genetics in Moscow. It extends the natural immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with the same stabilizing Pro-Gly-Pro tail used in Semax, which protects the active core from rapid enzymatic breakdown in experimental systems.
Research background
The preclinical literature on Selank concentrates on anxiety-related behavioral models in rodents, GABAergic signaling, and expression of neurotrophic factors including BDNF. Its tuftsin parentage also gives it a presence in immunomodulation studies. As with the wider Russian neuropeptide literature, methods and endpoints vary between groups — primary sources reward careful reading.
Structure and analytical profile
Selank is short, hydrophilic, and robust as a lyophilizate. On HPLC a quality lot presents a single dominant peak; identity is confirmed against a reference standard by retention time and spectral match. A proper certificate separates chromatographic purity (how much of the detected material is the target peptide) from net peptide content (how much of the vial’s mass is peptide versus counter-ion and water) — two numbers that are often conflated in marketing copy but mean different things at the bench.
Verifying a lot
Heartland Bio Labs publishes independent laboratory certificates for tested lots in the COA portal. Search the product name to read the transcribed results — purity, identity, content per vial, testing laboratory, and report date — with the original PDF attached. Earlier lots are retained rather than replaced.
Handling notes
Store lyophilized material cold, dry, and dark. Solutions are prepared fresh in laboratory practice.
Frequently asked research questions
Selank vs Semax — what is the actual difference?
Different parent molecules and different literatures: Selank derives from tuftsin and is studied mainly in anxiety and immune models; Semax derives from ACTH(4-10) and is studied mainly in neurotrophin and attention models. They share only the engineered Pro-Gly-Pro stability tail.
What strengths are typical?
Research vials are commonly offered at 5 mg and 10 mg.
All compounds discussed are for laboratory research use only and are not for human consumption. Nothing here is medical advice or a statement of clinical effect.
Product page: Selank.