Sermorelin is a synthetic peptide corresponding to the first 29 amino acids of human growth-hormone-releasing hormone — GHRH(1-29) — which is the shortest fragment of the native 44-residue hormone that retains full activity at the GHRH receptor in research models. That property made it one of the foundational compounds of GHRH pharmacology: much of what the literature knows about the receptor was characterized using this exact fragment, and nearly every later analogue in the class (including the modified variants like CJC-1295) is built on its scaffold.
Research background
GHRH research in the 1980s established that the biological activity of the native hormone resides almost entirely in its N-terminal 29 residues, and sermorelin is that finding turned into a compound. In receptor studies it behaves as a full agonist at the GHRH receptor, and its comparatively short half-life in circulation models — minutes, owing to rapid enzymatic cleavage — is itself a studied property: it is the reason stabilized analogues exist, and papers characterizing those analogues almost always use sermorelin as the reference compound. If you are reading receptor-pharmacology literature in this class, sermorelin is usually the baseline everything else is measured against.
Structure and analytical profile
Sermorelin is a single-chain 29-amino-acid peptide with a molecular weight of approximately 3,358 g/mol. Identity is established by mass spectrometry against that mass, and purity chromatographically; the analytically relevant impurities are truncated sequences from synthesis, which HPLC resolves. It is supplied as an acetate salt in lyophilized form.
Verifying a lot
The three checks that matter for anything in this catalog: the lot number on the certificate matches the vial in hand, the issuing laboratory is named with the original report attached, and the report verifies with the laboratory directly. Every sermorelin lot we sell publishes its certificate in the certificate archive, searchable by product and lot number.
Handling notes
Supplied lyophilized; store cool, dark and dry until laboratory use. Reconstituted solutions are handled cold and used promptly in research practice — the molecule’s enzymatic lability is well documented. For qualified laboratory settings only.
Frequently asked research questions
How does sermorelin differ from CJC-1295? CJC-1295 (Mod GRF 1-29) is the same 29-residue scaffold carrying four amino-acid substitutions for enzymatic stability; the DAC-conjugated form adds a further modification extending half-life in circulation models. Sermorelin is the unmodified fragment. See the CJC-1295 overview.
Why does its short half-life matter to researchers? Because it is the reference property the stabilized analogues were designed against — comparative stability studies in this class are anchored to sermorelin data.
What should a sermorelin certificate show? Identity by mass spectrometry consistent with ~3,358 g/mol, chromatographic purity resolving synthesis truncations, lot number, issuing laboratory, report date.
All products discussed are for laboratory research use only and are not for human or veterinary consumption. Nothing here describes or endorses any use in humans or animals.