Semax is a synthetic heptapeptide built from a fragment of adrenocorticotropic hormone, ACTH(4-7), with a Pro-Gly-Pro tail added for stability: Met-Glu-His-Phe-Pro-Gly-Pro. Developed in Russia in the 1980s and 1990s, it is one of the most studied compounds in the neuropeptide research field, and one of the few whose primary literature base sits largely outside English-language journals. Heartland Bio Labs supplies Semax for laboratory research in 10mg vials with independent purity and identity verification.
What Semax is
The parent molecule, ACTH, is a 39-amino acid hormone. Researchers isolated the 4-7 fragment for study because it carried activity of interest in cognition and neuroprotection models without the hormonal signaling of the full sequence, then stabilized it with the C-terminal Pro-Gly-Pro extension that gives Semax its usable half-life. The result is a small, well-characterized peptide that has anchored decades of Russian and, increasingly, international preclinical research on neurotrophic signaling, including work on BDNF expression in research models. Structural detail is in our Semax research overview.
A compound with an unusual literature
Semax comes out of a research tradition documented largely in Russian-language literature, which shapes what is and is not known about it. Our article on Semax and Selank, the Russian neuropeptides covers that history.
Semax's research base is distinctive: much of the foundational work was published in Russian-language journals, and the compound has a long history of study in that scientific tradition. For researchers, that cuts two ways. There is far more published work than an English-only search suggests, and far more variability in the quality of material sold under the name, since demand is global while characterization standards vary. That second point is why verification matters more for Semax than its size would suggest.
Product characteristics
- Synthetic heptapeptide: Met-Glu-His-Phe-Pro-Gly-Pro, ACTH(4-7) plus Pro-Gly-Pro
- Approximate molecular weight: 813.9 g/mol
- Supplied as white lyophilized powder in sealed vials
- Available strength: 10mg; a 5mg vial appears on the selector with a notify option when not in stock
- HPLC purity and mass spectrometry identity, tested by an independent laboratory
- For laboratory research use only
How this product is verified
Semax is analyzed by an independent laboratory, purity by HPLC and identity by mass spectrometry, with certificates published in our COA portal before you order. Small peptides make identity confirmation the critical test: a clean chromatogram cannot tell you the peak is Semax rather than a failed synthesis of it. Our article on HPLC vs mass spectrometry covers why both numbers need to be on the certificate.
Semax and Selank
Semax is almost always studied alongside Selank, its sibling in the Russian peptide literature. The two share the stabilizing Pro-Gly-Pro tail but come from different parents: Semax from ACTH, Selank from the immune tetrapeptide tuftsin. Research programs comparing neurotrophic and anxiolytic-model signaling typically order the pair, and we stock both.
Pricing, storage, and shipping
The 10mg vial is $95, in stock, shipping same-day from the Tulsa, Oklahoma area on orders before 2:00 PM Central. Store lyophilized vials sealed, cool, dry, and away from light; reconstitute with bacteriostatic water and refrigerate the solution. Volume needs run through our wholesale program, and our guide to vetting a research peptide supplier is the checklist to hold any vendor to.
Reconstitution math
Work out concentration (mg/mL), amount per volume and molarity for any vial size with the general peptide calculator. For the bench procedure see how to reconstitute peptides.
Research use only
Semax from Heartland Bio Labs is sold strictly for laboratory research and identification purposes. It is not a drug, it has not been evaluated by the FDA, and it is not for human or veterinary use of any kind. By purchasing, you affirm that you are qualified to handle research compounds and agree to our research use policy.
